Microwave Assisted Synthesis and Evaluation of Cross-Linked Carboxymethylated Sago Starch as Superdisintegrant
نویسندگان
چکیده
The aim of this study was to modify the sago starch and evaluate its efficacy as tablet disintegrant. Cross-linked carboxymethylated sago starch (CMSS) was synthesized using native sago starch (SS) and monochloroacetic acid (MCA) with sodium hydroxide in microwave radiation environment. FT-IR analysis of the sample confirmed the carboxymethylation by showing absorption peak at 1607.2 cm. CMSS with degree of substitution (DS) of 0.31 was formed and, it was further evaluated as disintegrant in Ondasetron based tablets. The results revealed that CMSS could be used as disintegrant in tablet formulation in concentration dependant manner.
منابع مشابه
Microwave-Assisted Synthesis of CuFe2O4 Nanoparticles and Starch-Based Magnetic Nanocomposites
Magnetic CuFe2O4 nanoparticles were synthesized by a facile microwave-assisted reaction between Cu(NO3)2 and Fe(NO3)3. The magnetic nanoparticles were added to starch to make magnetic polymeric nanocomposite. The nanoparticles and nanocomposites were characterized using X-ray diffraction and scanning electron microscopy. The magn...
متن کاملEffects of phosphorylation and cross-linking on the pasting properties and molecular structure of sago starch
Native sago starch was phosphorylated with 5% sodium tripolyphosphate (STPP) or crosslinked with 4% phosphorous oxychloride (POCl3) at pH 8 to 11. The modified starches were characterized for degree of substitution (DS), pasting properties, crystallinity and molecular structure. The results indicated that DS of phosphorylated sago starch prepared at pH 9 was 0.008, which was the highest value a...
متن کاملDevelopment of Corn Starch-Neusilin UFL2 Conjugate as Tablet Superdisintegrant: Formulation and Evaluation of Fast Disintegrating Tablets
In the present study, corn Starch-Neusilin UFL2 conjugates were prepared by physical, chemical, and microwave methods with the aim of using the conjugates as tablet superdisintegrant. Various powder tests, namely, angle of repose, bulk density, tapped density, Hausner's ratio, Carr's index, swelling index, and powder porosity were conducted on the samples. The conjugates were characterized by A...
متن کاملEffects of different temperature profiles and corn-sago starch ratios on physical properties of extruded tilapia diets
Sago starch is a locally grown and produced starch resource in Malaysia. In this study, corn starch to sago starch ratios (CS:SS) of 0:20, 5:15, 10:10, 15:5 and 20:0 were included in feed mixture to contain 20% starch and produce five isonitrogenous and isocaloric (30% crude protein and 16.7 kJ/g, respectively) tilapia Oreochromis sp. diets. Diets were preconditioned to contain 40% moisture and...
متن کاملMicrowave-Assisted Synthesis of kappa-Carrageenan Beads Containing Silver Nanoparticles with Dye Adsorption and Antibacterial Properties
In this work, we used a simple and totally green method for synthesizing silver nanoparticles using kappa-carrageenan as reducing and stabilizing agent. The beads were prepared in aqueous medium by microwave heating, and then followed by cross-linking with K+ cations without using any additional toxic and expensive chemical agents. The preparation method of the carrageenan-based beads is easy, ...
متن کامل